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    徐溢新, 刘佳, 刘广珍, 宋虎, 许腾, 江涛, 宋军. 肿瘤出芽与结直肠癌临床病理特征及预后的相关性分析[J]. 徐州医科大学学报, 2020, 40(12): 864-869. DOI: 10.3969/j.issn.2096-3882.2020.12.002
    引用本文: 徐溢新, 刘佳, 刘广珍, 宋虎, 许腾, 江涛, 宋军. 肿瘤出芽与结直肠癌临床病理特征及预后的相关性分析[J]. 徐州医科大学学报, 2020, 40(12): 864-869. DOI: 10.3969/j.issn.2096-3882.2020.12.002
    Correlation analysis of tumor budding on clinicopathological characteristics and prognosis of colorectal cancer[J]. Journal of Xuzhou Medical University, 2020, 40(12): 864-869. DOI: 10.3969/j.issn.2096-3882.2020.12.002
    Citation: Correlation analysis of tumor budding on clinicopathological characteristics and prognosis of colorectal cancer[J]. Journal of Xuzhou Medical University, 2020, 40(12): 864-869. DOI: 10.3969/j.issn.2096-3882.2020.12.002

    肿瘤出芽与结直肠癌临床病理特征及预后的相关性分析

    Correlation analysis of tumor budding on clinicopathological characteristics and prognosis of colorectal cancer

    • 摘要: 目的 探讨肿瘤出芽与结直肠癌临床病理特征的关系及对结直肠癌患者预后的影响,为结直肠癌临床诊治和预后评价提供新方向.方法 选取2015年1月—12月徐州医科大学附属医院胃肠外科收治的未经放化疗的结直肠癌患者285例作为研究对象,根据肿瘤出芽水平分为低肿瘤出芽组和高肿瘤出芽组,分析肿瘤出芽与结直肠癌临床病理特征的关系;通过随访,分析肿瘤出芽与肿瘤预后的相关性.结果 高肿瘤出芽组中低组织学分级、高浸润深度和复发患者比例显著高于低肿瘤出芽组,差异有统计学意义(P<0.05);多因素COX回归分析显示,肿瘤出芽是结直肠癌患者预后的独立危险因素(HR=2.663,95%CI:1.534~3.878,P<0.001).结论 肿瘤出芽与结直肠癌侵袭相关指标关系密切,是影响结直肠癌患者预后的重要危险因素.

       

      Abstract: ob<x>jective: To explore the relationship between tumor budding and clinicopathological characteristics of colorectal cancer, and to study the influence of tumor budding on the prognosis of patients with colorectal cancer, so as to provide a new direction for clinical diagnosis, treatment and prognosis evaluation of colorectal cancer. Methods: 285 cases of colorectal cancer without radiotherapy and chemotherapy from January 201 5 to December 2015 in the Department of Gastroenterology, Affiliated Hospital of Xuzhou Medical University were selected as the research ob<x>ject. According to the level of tumor budding, they were divided into low budding group and high budding group. The relationship between tumor budding and clinical pathological characteristics of colorectal cancer was analyzed; the relationship between tumor budding and tumor prognosis was analyzed in follow-up patients. Results: the proportion of patients with low histological grade, invasion type, high depth of invasion and recurrence in the high tumor budding group was significantly higher than that in the low tumor budding group, and the difference was statistically significant(P<0.05); multivariate Cox regression analysis showed that tumor budding was the independent risk factor for the prognosis of colorectal cancer patients (HR=2.663, 95%CI:1.534~3.878, P<0.001). Conclusion: tumor budding is related to the invasion of colorectal cancer. Tumor budding is an important risk factor for the prognosis of colorectal cancer patients.

       

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