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《徐州医科大学学报》[ISSN:2096-3882/CN:32-1875/R]

卷:

41

期数:

2021年04期

页码:

284-288

栏目:

出版日期:

2021-04-25

文章信息/Info

Title:

Distribution characteristics and drug resistance analysis of 562 strains of Streptococcus pneumoniae from hospitalized children in Suqian region

作者:

蒋亚洲1; 闫京京1; 沈男1; 尹瀚浚1; 王胜2; 陈敏3; 王金娜4*

1.徐州医科大学附属宿迁医院，南京鼓楼医院集团宿迁市人民医院儿科，江苏宿迁223800；2.徐州医科大学附属宿迁医院，南京鼓楼医院集团宿迁市人民医院检验科;3.徐州市第一人民医院，江苏徐州221000；4.徐州医科大学附属宿迁医院，南京鼓楼医院集团宿迁市人民医院药剂科

关键词:

肺炎链球菌; 耐药性; 儿童; 抗菌药物

分类号:

R378.1

DOI:

10.3969/j.issn.2096-3882.2021.04.011

文献标志码:

A

摘要:

目的评价宿迁地区住院患儿肺炎链球菌的感染分布特点及耐药性变化趋势。方法收集宿迁市人民医院2017年1月—2019年12月收治的肺炎链球菌感染的患儿病历，统计一般资料、送检标本特征和药敏试验结果。结果我院住院患儿共分离出3 239株病原菌，其中肺炎链球菌562株，男性患儿占63.52%。3岁以下患儿检出率较高（87.9%）。送检标本主要来源于痰液、血液、肺泡灌洗液等，其中痰液共分离出444株肺炎链球菌（79.00%）。肺炎链球菌可能会合并流感嗜血杆菌、呼吸道合胞病毒、流感病毒、肺炎支原体或腺病毒感染，其中合并呼吸道合胞病毒的感染率较高（14.59%）。肺炎链球菌对阿莫西林、厄他培南、氧氟沙星、左氧氟沙星、莫西沙星、泰利霉素、利奈唑胺、万古霉素、氯霉素较敏感（92.95%~100%），对红霉素、四环素和复方新诺明耐药率较高（73.65%~99.43%）。结论肺炎链球菌主要通过呼吸道感染3岁以下儿童，男性患儿居多，且合并其他病原体的情况不容忽视。药敏结果显示宿迁地区儿童肺炎链球菌感染可首选阿莫西林、三代头孢或青霉素。

Abstract:

ObjectiveTo evaluate the distribution characteristics and drug resistance of Streptococcus pneumoniae infection in child patients within Suqian area.MethodsA retrospective analysis was performed using clinical data from child patients who was admitted in the Affiliated Suqian Hospital of Xuzhou Medical University due to Streptococcus pneumoniae infection from January 2017 to December 2019. Their general information was collected and the characteristics of the samples and drug sensitivity were analyzed. ResultsA total of 3 239 strains of pathogens were isolated from the patients, including 562 strains of Streptococcus pneumonia in which 357 strains (63.52%) of Streptococcus pneumoniae was isolated from boys. With a higher positive rate in children under three years old(87.9%).The samples were mainly from the sputum, blood, bronchoalveolar lavage fluid, et al, where 444 strains (79.00%) of Streptococcus pneumoniae were isolated from the sputum. The patients may be also co-infected with Haemophilus influenzae, respiratory syncytial virus, influenza virus, Mycoplasma pneumoniae or adenovirus, where the infection rate of Streptococcus pneumoniae combined with respiratory syncytial virus was high (14.59%). Streptococcus pneumoniae was more sensitive to amoxicillin, ertapenem, ofloxacin, levofloxacin, moxifloxacin, telithromycin, linezolid, vancomycin and chloramphenicol (92.95%-100%), with high drug resistance to erythromycin, tetracycline and compound neonomine (73.65%-99.43%).ConclusionsStreptococcus pneumoniae mainly infects children under three-year-old through the respiratory tract, especially for boys. Meanwhile, some of the patients were also infected with other pathogens in addition to Streptococcus pneumoniae. For child patients with Streptococcus pneumoniae infection in Suqian area, the first choice is amoxicillin, the third generation cephalosporins or penicillin.

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更新日期/Last Update: 2021-05-12