Abstract:
ob<x>jective To explore the prognostic value of pretreatment cholinesterase(ChE) and neutrophil-to-lymphocyte (NLR) in the patients with me<x>tastatic gastric cancer . Methods We retrospectively enrolled 101 patients who were pathologically diagnosed with me<x>tastatic gastric cancer and treated with first-line chemotherapy at the Affiliated Huai’an Hospital of Xuzhou Medical University between January 2012 to October 2020 into this study. The optimal cutoff values of ChE and NLR were calculated by X-tile program. Association between ChE, NLR and other clinicopathological characteristics was determined by chi-square test. Pearson correlation analyses were applied to analyze the correlation among ChE and NLR. Kaplan-Meier methods were used to analyze the correlations of ChE and NLR with the OS of patients . Multivariate COX regression was used to analyze the predictors significantly associated with OS, and R software was used to draw the nomogram, which was verified internally. Results Multivariate analysis showed that ChE、NLR、ECOG and CA-199 were independent influencing factors of OS in patients with me<x>tastatic gastric cancer. These independent factors were taken into account to construct a nomogram prediction model. This model had good discrimination and calibration and the C-index of the nomogram prediction model in this study was 0.673. Predictive nomograms and time-independent receiver operating characteristic (ROC) curve that included the ChE score group were superior to those without ChE scores.Conclusion There are certain value for ChE and NLR in predicting the prognosis of patients with me<x>tastatic gastric cancer. The nomogram including ChE has a good coincidence and can accurately predict the prognosis of me<x>tastatic gastric cancer