Abstract:
ob<x>jective: To investigate the predictive value of ADC texture analysis on preoperative DWI for postoperative recurrence and the relationship with progression free survival time in epithelial ovarian cancer (EOC). Methods: A total of 84 patients with surgically and histopathologically confirmed EOC from January 20 19 to January 20 20 in our hospital were retrospectively analyzed, clinical data and preoperative DWI imaging were collected, and 43 patients were divided into recurrence and 41 non recurrence groups according to the 1-year post recurrence results, and the clinical data and ADC texture parameters (kurtosis, 10th percentile, 25th percentile, inertness, correlation, contrast, variationEntropy values) difference, logistic regression analysis of the risk factors for EOC recurrence, ROC curve analysis of the efficacy of the risk factors to predict EOC recurrence was applied, followed up for 36 months, to compare the survival time of EOC patients grouped by different risk factors.Results: There were significant differences in CA125, HE4, ALB, tumor size and FIGO stage at first diagnosis between recurrence groups (P<0.05);The 10th percentile, 25th percentile, correlation were significantly lower in the recurrence group than in thenon recurrence group( P<0.05), and the values of inertness, contrast, mutation, and entropy were significantly higher in the recurrence group than in the non recurrence group ( P<0.05);After logistic regression analysis, tumor size, FIGO stage, indolence, correlation were independent risk factors for EOC recurrence (P <0.05);ROC curve analysis showed that the combination of tumor size, FIGO stage, indolence, correlation predicted recurrence with the largest AUC area of 0.992;The survival time of patients with tumor diameter<55.374, FIGO stage<2, indolent<696.74, and correlation ≥ 0.000425 was significantly higher than that of patients with tumor diameter ≥ 55.374, FIGO stage ≥ 2, indolent ≥ 696.74, and correlation < 0.000425 (P<0.05).Conclusions: ADC texture analysis on preoperative DWI of EOC is helpful in predicting EOC recurrence and survival time.