[1]高照华,火焱,王昭玲,等.血清CEA、NSE、CA199、CA153、CA125对2型糖尿病视网膜病变的预测价值[J].徐州医科大学学报,2022,42(03):181-188.[doi:10.3969/j.issn.2096-3882.2022.03.005]
 Predictive values of serum NSE, CA199 and CA125 in type 2 diabetic retinopathy[J].Journal of Xuzhou Medical University,2022,42(03):181-188.[doi:10.3969/j.issn.2096-3882.2022.03.005]
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血清CEA、NSE、CA199、CA153、CA125对2型糖尿病视网膜病变的预测价值()
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《徐州医科大学学报》[ISSN:2096-3882/CN:32-1875/R]

卷:
42
期数:
2022年03期
页码:
181-188
栏目:
出版日期:
2022-03-25

文章信息/Info

Title:
Predictive values of serum NSE, CA199 and CA125 in type 2 diabetic retinopathy
作者:
高照华火焱王昭玲胡浩王勃孙进裴颖刘媛媛周婷婷尹雯雯蔡若男*
徐州市第一人民医院内分泌科,江苏徐州221000
关键词:
2型糖尿病视网膜病变神经元特异性烯醇化酶糖类抗原199糖类抗原125预测价值
分类号:
R587.1
DOI:
10.3969/j.issn.2096-3882.2022.03.005
文献标志码:
A
摘要:
目的:探讨肿瘤标志物如癌胚抗原(CEA)、神经元特异性烯醇化酶(NSE)、糖类抗原199(CA199)、糖类抗原153(CA153)、糖类抗原125(CA125)以及甲胎蛋白(AFP)在2型糖尿病视网膜病变患者中的预测价值。方法:收集本院2019年1月至2019年12月住院的2型糖尿病(T2DM)患者306例,分为糖尿病合并视网膜病变组(DR组,n=134)和未合并视网膜病变组(NDR组,n=172)。比较两组血清肿瘤标志物及病程、年龄、空腹血糖(FPG)、糖化血红蛋白(HbA1c)、C肽、尿微量白蛋白/肌酐(ALB/SCr)、甘油三酯(TG)、总胆固醇(TC)等水平。Spearman法分析DR患者血清肿瘤标志物与一般资料的相关性,Logistic多元回归法分析DR危险因素,绘制ROC曲线。结果:DR组患者年龄、病程、CEA、NSE、CA199、CA153、CA125、ALB/SCr、胱抑素C(Cys-C)、尿素氮(BUN)、HbA1c均明显高于NDR组(P<0.05),c肽、肾小球滤过率(GFR)明显低于NDR组(P<0.05)。DR患者CEA、CA199与HbA1c呈正相关,NSE与TC、低密度脂蛋白(LDL-C)呈正相关,CA125与ALB/SCr、高密度脂蛋白(HDL-C)呈正相关(P<0.05)。不同病程(≥10年、1-10年、<1年)DR患者CEA、NSE、CA199、CA153、CA125水平差异有统计学意义(P<0.05),不同年龄(≥60岁、40-60岁、<40岁)DR患者CEA、NSE、CA199、CA153水平差异有统计学意义(P<0.05)。Logistic多元回归分析,T2DM病程、ALB/SCr、NSE、CA199、CA125为DR的危险因素(P<0.05,OR>1)。DR患者CEA、NES、CA199、CA153、CA125诊断曲线下面积(AUC)分别为0.669、0.798、0.674、0.687、0.669(P<0.05),其中NSE对应曲线下面积最大,阈值为11.745,灵敏度为82.8%,特异度为67.4%。结论:血清NSE、CA199、CA125均为DR危险因素,CEA、NES、CA199、CA153、CA125对诊断DR有一定的预测价值,尤其NSE诊断DR的价值最高。
Abstract:
ob<x>jective: To investigate the predictive values of carcinoembryonic antigen (CEA), neuron specific enolase (NSE), carbohydrate antigen 199 (CA199), carbohydrate antigen 153 (CA153), carbohydrate antigen 125 (CA125) and alpha fetoprotein (AFP) in patients with type 2 diabetic retinopathy.Methods: 306 patients with type 2 diabetes (T2D) were enrolled and divided into diabetic retinopathy (DR, n=134) and non-DR group (NDR, n=172). The levels of serum tumor markers and clinical characteristics were compared between the two groups. Spearman correlation analysis was employed to analyze the correlation between serum tumor markers and clinical characteristics. The logistic multiple regression was implemented to analyze the risk factors of DR. The area under curve (AUC) was obtained.Results: Age, history of T2D, CEA, NSE, CA199, CA153, CA125, ALB / SCR, Cys-C, blood urea nitrogen (BUN) and HbA1c in DR group were significantly higher than those of NDR group (P < 0.05). CEA and CA199 were positively correlated with HbA1c, NSE was positively correlated with TC and LDL-C, and CA125 was positively correlated with ALB / SCR and HDL-C (P < 0.05). The levels of tumor markers were significantly increased with T2D history and age (P < 0.05). The history of T2D, ALB / SCR, NSE, CA199 and CA125 were risk factors for DR (P < 0.05, or > 1). The AUC of CEA, NES, CA199, CA153 and CA125 in DR patients were 0.669, 0.798, 0.674, 0.687 and 0.669, respectively (P < 0.05). Diagnostic sensitivity and specificity of NSE was 82.8% and 67.4%.Conclusion: CEA, NES, CA199, CA153 and CA125 have certain diagnostic value for DR.

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备注/Memo

备注/Memo:
基金项目:中国矿业大学青年科技基金(2020QN81)*通信作者,E-mail:crn86@163.com
更新日期/Last Update: 2022-05-09