Abstract: Objective To explore the feasibility, safety and accuracy of computed tomography (CT)-guided coil localization combined with abdominal belts for thoracoscopic resection of lung nodules. Methods A total of 100 patients with small pulmonary nodules who were admitted in the Affiliated Hospital of Xuzhou Medical University from July 2021 to December 2021 were selected and their clinical data were retrospectively analyzed. According to their methods of localization, they were divided into two groups (n=50). The experiment group used coil localization in addition to abdominal belts, while the control group used metal coil alone to localize lung nodules. Both groups were compared for the duration of localization, localization success rate, localization complications, and nodules resection time. Results The duration of localization in the experiment group was (19.62±0.36) min, which was significantly shorter than that in the control group (21.66±0.51) min（P<0.01). The experiment group showed a remarkably less incidence of complications than the control group. However, there was no significant difference in the resection time and positionging success rate between the two groups (P>0.05). Conclusions CT-guided coil localization combined with abdominal belts for lung nodules resection is safe, effective and easy to perform, with less positioning complications.