Abstract: Alzheimer's disease (AD) is one of the most common diseases among the elderly worldwide. Its prevalence continues to rise, but the disease still lacks effective treatments, imposing a heavy burden on both individuals and the society. Silent information regulator factor 2 (SIRT2) is a nicotinamide adenine dinucleotide-dependent deacetylase involved in multiple biochemical pathways, including inflammatory responses, oxidative damage, and apoptosis. This paper summarizes the biological characteristics of SIRT2 and its role in AD and related research progress. Special focus is given to the structure and function of SIRT2, its effect on the pathological marks of AD β-amyloid and Tau protein, and its involvement in SIRT2-mediated neuroinflammation, oxidative stress, and autophagy. These findings will provide insights into developing novel therapeutic strategies for AD.