Abstract: Non-coding RNAs (ncRNAs) have gained increasing attention in the study of diabetic nephropathy (DN). DN is one of the most common chronic complications of diabetes and a major cause of end-stage renal disease in diabetic patients. The pathogenesis of DN is complex and involves multiple pathophysiological processes. Among them, pyroptosis is an important molecular mechanism in DN and has become a hot research topic in recent years. Pyroptosis is a form of programmed cell death that is closely associated with inflammatory responses, characterized by the release of cellular contents and the activation of inflammatory cytokines. ncRNAs play a crucial role in regulating pyroptosis and may serve as potential therapeutic targets for DN. This review summarizes the research progress on the role of ncRNAs in regulating pyroptosis in DN and explores their potential therapeutic significance.