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    吴晶, 刘鹏来, 李安安. 嗅觉与癫痫:梨状皮层的关键作用[J]. 徐州医科大学学报. DOI: 10.12467/j.issn.2096-3882.20240654
    引用本文: 吴晶, 刘鹏来, 李安安. 嗅觉与癫痫:梨状皮层的关键作用[J]. 徐州医科大学学报. DOI: 10.12467/j.issn.2096-3882.20240654
    WU Jing, LIU Penglai, LI Anan. Olfaction and epilepsy: the key role of the piriform cortex[J]. Journal of Xuzhou Medical University. DOI: 10.12467/j.issn.2096-3882.20240654
    Citation: WU Jing, LIU Penglai, LI Anan. Olfaction and epilepsy: the key role of the piriform cortex[J]. Journal of Xuzhou Medical University. DOI: 10.12467/j.issn.2096-3882.20240654

    嗅觉与癫痫:梨状皮层的关键作用

    Olfaction and epilepsy: the key role of the piriform cortex

    • 摘要: 癫痫是最常见的慢性神经系统疾病之一,其特征是反复的癫痫发作,与过度或超同步的神经元活动有关。临床研究表明,癫痫患者常常伴有嗅觉功能障碍,这可能是癫痫发作的一个重要临床标志。近年来的研究揭示了梨状皮层———一个与嗅觉处理密切相关的脑区———在癫痫发病机制中的重要作用。本文旨在全面回顾梨状皮层在癫痫中的研究进展,总结现有治疗策略,对梨状皮层作为潜在治疗靶点的可能性进行进一步探讨,并为未来研究方向提供展望以促进癫痫机制的深入理解和新型疗法的发展。

       

      Abstract: Epilepsy is one of the most common chronic neurological disorders, characterized by recurrent epileptic seizures linked to excessive or hypersynchronous neuronal activity. Clinical studies have shown that patients with epilepsy often exhibit olfactory dysfunction, which may serve as a clinical marker of disease progression. Recent research has unveiled the crucial role of the piriform cortex-a brain region closely related to olfactory processing-in the pathogenesis of epilepsy. The current article aims to comprehensively review the research progress on the piriform cortex in epilepsy, summarize existing therapeutic strategies, further explore the potential of the piriform cortex as a therapeutic target, and offer insights into future research directions to facilitate a deeper understanding of the mechanisms of epilepsy and the development of novel therapeutic approaches.

       

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