Abstract: Objective To evaluate the effects of intracranial electrical stimulation on brain function and brain networks in patients with drug-resistant epilepsy (DRE). Methods The small-world properties, assortativity, and hierarchy of functional connectivity networks were compared between the resting state and the simultaneous electrical stimulation state in patients with DRE. In addition, the Network-Based Statistic (NBS) method was applied to analyze differential connectivity patterns between the two conditions. Results No significant differences were found in network topological properties between the two conditions. However, under simultaneous electrical stimulation, the brain network showed a trend toward decreased small-worldness, along with increased assortativity and decreased hierarchy. NBS analysis identified a differential subnetwork primarily involving the frontal lobe, prefrontal cortex, and temporal lobe. Conclusions Under simultaneous electrical stimulation, functional connectivity networks in patients with DRE may exhibit a trend toward weakened small-world properties, elevated network assortativity, and reduced hierarchy of major functional networks. Frontal and prefrontal regions may be more strongly recruited to participate in brain network activity during electrical stimulation.