Abstract: Objective To explore the construction of a multidimensional comprehensive intervention model for sepsis during the rehabilitation period and evaluate its clinical application.Methods This is a randomized controlled study. A total of 110 sepsis patients who were transferred from the ICU were selected and divided into two groups (n=55) using block randomization: an intervention group and a control group. Patients in the intervention group received multidimensional comprehensive intervention, including remote monitoring, step-down antibiotic therapy, nutritional support, exercise rehabilitation, psychosocial intervention, and traditional Chinese medicine therapy. Those in the control group underwent routine treatment. Primary outcome was the 30-day readmission rate.Results The intervention group showed significantly higher blood oxygen saturation, urine output, and muscle strength (MRC score) than the control group (all P<0.05). Heart rate and procalcitonin levels were significantly lower in the intervention group (all P<0.05). Compared with the control group, the intervention group showed significant reduction in the incidence of complications and 30-day readmission rate and increases in SF-36 quality of life scores and Barthel index scores (all P<0.05).Conclusions The multidimensional comprehensive intervention model during the rehabilitation period of sepsis can effectively improve patients' physiological functions, reduce complications and readmission risks, enhance quality of life and self-care ability, with good clinical application and promotion value.