高级检索

    术前衰弱与老年髋部骨折患者术后死亡的关系

    Association between preoperative frailty and postoperative mortality in elderly patients with hip fracture

    • 摘要: 目的 探讨术前衰弱对老年髋部骨折患者术后1年全因死亡的影响。方法 选取2018年1月—2023年12月海军军医大学附属长海医院收治的老年髋部骨折患者,收集临床资料进行回顾性分析。评估术前改良衰弱指数(mFI-5),以术前mFI-5≥2分定义为衰弱状态。采用多因素Cox比例风险回归模型评估术前衰弱与术后1年全因死亡的关联,并进行亚组分析。采用Kaplan-Meier法绘制生存曲线,比较不同组别的生存差异。结果 共纳入1 715例患者,术后1年内死亡158例(9.2%)。多因素Cox回归分析显示,术前衰弱与术后1年全因死亡风险升高独立相关(HR=1.66, 95%CI=1.17~2.36, P=0.004)。Kaplan-Meier生存曲线显示,衰弱组术后1年死亡率高于非衰弱组(Log-rank检验P=0.009)。亚组分析结果提示,术前衰弱与死亡风险增加的关联在各亚组中总体一致,且未观察到显著交互作用(均P>0.05)。结论 术前衰弱是老年髋部骨折患者术后1年全因死亡的独立危险因素。开展术前衰弱评估有助于早期识别高风险患者,为围手术期风险分层与干预策略制定提供参考。

       

      Abstract: Objective To investigate the impact of preoperative frailty on 1-year all-cause mortality in elderly patients after hip fracture surgery. Methods Elderly patients with hip fractures, who were admitted to Changhai Hospital, Naval Medical University, between January 2018 and December 2023 were selected, and their clinical characteristics were retrospectively analyzed. The preoperative modified frailty index (mFI-5) was assessed, where frailty was defined as a preoperative mFI-5 score ≥2. A multivariable Cox proportional hazards regression model was used to evaluate the association between preoperative frailty and 1-year postoperative all-cause mortality, with subgroup analyses performed. Kaplan-Meier survival curves were plotted to compare survival differences between the groups. Results A total of 1,715 patients were included, of whom 158 (9.2%) died within 1 year after surgery. Multivariable Cox regression analysis showed that preoperative frailty was independently associated with an increased risk of 1-year all-cause mortality after surgery (HR=1.66, 95%CI=1.17-2.36, P=0.004). Kaplan-Meier survival curves showed that the frailty group had a higher 1-year postoperative mortality rate than the non-frailty group (P=0.009). Subgroup analyses indicated that the association between preoperative frailty and increased mortality risk was generally consistent across subgroups, with no significant interactions observed (P>0.05). Conclusions Preoperative frailty is an independent risk factor for 1-year all-cause mortality in elderly patients after hip fracture surgery. Preoperative frailty assessment may help identify high-risk patients early and provide reference for perioperative risk stratification and the development of targeted intervention strategies.

       

    /

    返回文章
    返回