Abstract: Objective To compare and analyze the curative effect of modified Ivor-Lewis operation and traditional Ivor-Lewis operation in the treatment of esophageal cancer,so as to provide reference for the selection of surgical methods in clinical treatment. Methods The clinical data of 150 patients with esophageal cancer were retrospectively analyzed.The number of lymph node dissection,operation time,intraoperative bleeding volume,anal exhaust,first time out of bed and hospital stay and recurrence after Ivor-Lewis operation and modified Ivor-Lewis operation were compared and analyzed. Results The time of hospitalization,first time for being able to get out of bed and postoperative anal exhaust time in the observation group was significantly shorter than that in the control group（P＜0.05）,the degree of pain after operation was significantly less than that in the control group（P＜0.05）,the incidence of pulmonary infection and anastomotic leakage was significantly lower than that in the control group（P＜0.05）.There was no significant difference in recurrence rate and 1-year survival rate between the follow-up group and the control group（P＞0.05）.Conclusions Modified Ivor-Lewis operation combined with laparoscopy can effectively relieve postoperative pain and reduce the incidence of complications.It is a safe and effective minimally invasive surgical treatment for esophageal cancer.