Abstract: Objective To explore the effect of cluster strategy on treatment compliance and clinical rehabilitation of children with bronchial asthma. Methods A total of 128 children with asthma were divided into a control group and an observation group（n=64 each）.The two groups-were given standardized treatment of asthma.The control group was treated with traditional management mode,and was given disease-related knowledge education and medication guidance in outpatient clinic.In the observation group,cluster strategy was implemented during the whole course of treatment.The management team and follow-up management center of asthmatic children were set up by specialists,nurses and nutrition experts.Good partnership was established.Psychological nursing such as comfort and encouragement was given to the children and their parents,so as to eliminate their resistance to standardized management mode,and to work out defensive measures,follow-up and exercise plans for daily life as well as interactive inhalation techniques.Nutrition experts conducted nutritional assessment and dietary guidance.The treatment compliance,pulmonary function and the control level of asthma were compared between the two groups. Results The compliance of treatment in acute attack and remission stage of asthma in the observation group was higher than that in the control group,and the duration of long-term inhalation therapy and specific immunotherapy in the remission stage of the observation group was longer than that in the control group,with statistical significance（P＜0.01）.The improvement of pulmonary function in the observation group was better than that in the control group,and the control level of asthma in the observation group was better than that of control group,with statistical significance（P＜0.01）.Conclusions Standard therapy combined with continuous cluster strategy can improve treatment compliance of asthma children,effectively improve lung function and achieve the clinical goals of asthma control.