地尔硫&#17644;对氯胺酮镇痛效应的影响

纪昊; 刘超; 王雅; 房谈谈; 奚鑫艳; 朱秀秀; 汤苏红; 高苏楠; 徐倩文; 李紫娴; 武静茹

doi:10.3969/j.issn.2096-3882.2019.09.03

地尔硫䓬对氯胺酮镇痛效应的影响

The effect of diltiazem on the analgesic effect of ketamine

摘要

摘要: 目的观察地尔硫䓬对氯胺酮镇痛效应的影响。方法将64只昆明种小鼠随机分成4组(n = 16):生理盐水(normal saline,NS)组、氯胺酮(ketamine,K)组、地尔硫䓬(diltiazem,D)组和地尔硫䓬+氯胺酮(diltiazem＋ketamine,D+K)组,均以腹腔注射给药。给药15 min后进行热板法疼痛实验和扭体法疼痛实验,测定各组小鼠热刺激缩足反射潜伏期(paw withdrawal thermal latency,PWTL)和15 min内扭体次数。结果与NS组相比,K组和D+K小鼠在给药后第15、25、35、45、55 min 的PWTL明显延长(P < 0.05);扭体次数明显减少(P< 0.05)。与K组相比,D+K组小鼠在给药后第25、35、55 min 的PWTL明显延长(P < 0.05);扭体次数明显减少(P< 0.05)。结论地尔硫䓬可显著增强氯胺酮的镇痛效应。

Abstract: Objective To observe the effect of diltiazem on the analgesic effect of ketamine in mice. Methods A total of 64 Kunming mice were randomly divided into 4 groups: group NS, group D (diltiazem), group K (ketamine) and group D+K (diltiazem+ketamine). The paw withdrawal thermal latency (PWTL) at certain points of time were measured 15 min after intraperitoneal injection.through hot-plate tests and the times of body-torsion within 15 min were tested through body torsion tests. Results Compared with group NS, group K and group D+K presented obviously longer PWTL at 15, 25, 35, 45 and 55 min after intraperitoneal injection and less body-torsion times within 15 min after intraperitoneal injection (P<0.05). In contrast with group K, the PWTL at 25, 35 and 55 min of group D+K were significantly prolonged and the body-torsion times within 15 min were decreased remarkably (P<0.05). Conclusions Diltiazem could improve the analgesic effect of ketamine in mice.

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