Abstract: Objective To study the effect of modified nasal oxygen tube on oxygen inhalation in stroke patients. Methods A total of 87 patients with hemiplegia after stroke were randomly divided into an observation group (n=41) and a control group (n=46). The observation group used modified nasal oxygen tube to inhale oxygen, while the control group used conventional nasal oxygen tube to inhale oxygen. The percutaneous oxygen saturation, nasal oxygen tube shedding rate and patients' satisfaction with nasal oxygen tube in the two groups were observed. Results On the first day of oxygen inhalation treatment, there was no significant difference in percutaneous oxygen saturation between the two groups (P>0.05). After one week of oxygen inhalation treatment, the fall-off rate of nasal oxygen tube in the observation group was lower than that in the control group (4.88% vs. 21.74%, P<0.05). The satisfaction degree of nasal oxygen tube in the observation group was slightly higher than that in control group (95.12% vs. 89.13%, P < 0.05). Conclusions The improved nasal oxygen tube can not only ensure the effect of oxygen inhalation in stroke patients with hemiplegia, but also reduce the fall-off rate of nasal oxygen tube and improve the satisfaction of patients with oxygen inhalation by nasal oxygen tube, which is worthy of clinical application.