Abstract: Objective To analyze the correlation between surgical procedures and postoperative complication on totally implantable access port (TIAP) via the right jugular vein. Methods A total of 749 patients who received TIAP via the right jugular vein at Beijing Shijitan Hospital from March 2012 to March 2017 were included in the current retrospective study. The correlation between surgical procedures, catheter-related infection, abnormal catheter position and duct blockage and other post-operative complications were analyzed. Results There were 9 patients with TIAP-related infection, 6 patients who underwent secondary operation for abnormal catheter position, and 9 patients with duct blockage. Furthermore, there were also 4 cases of duct break, 2 cases of pump body reversal and 1 case of skin ulceration. According to Cox regression analysis, the post-operational infection risks were B-type ultrasonography fixed position during operation and extended operation time. The average distance of the catheter over the carina was (4.64±0.43) cm in patients using X-ray for fixed position during surgery, which was statistically different from the average distance (3.44±1.12) cm of those without fixed position through X ray during surgery (P<0.05). Both average distances were less than 6 cm, the optical value required in the guidelines. The risk factors of catheter blockage were sharp angles of the catheter turn-back and no drawn blood. Conclusions Appropriate operation procedures can reduce the risk of post-operative complication after using TIAP via the right jugular vein.