Clinical value of serum ANXA1 in biliary tract tumors patients
-
摘要: 目的 检测胆道系统肿瘤患者外周血中膜联蛋白A1(ANXA1)的水平,分析其在肿瘤早期诊断和疾病进展评估中的临床价值。方法 采用ELISA检测胆道系统肿瘤患者术前和术后血清中ANXA1水平,并以健康人群血清ANXA1水平作为对照进行比较。结果 术前胆道系统肿瘤患者血清ANXA1水平为(348.36±236.53)μg/L,高于健康对照者血清中ANXA1水平(225.01±245.23)μg/L,2者比较差异无统计学意义(P>0.05)。胆道系统肿瘤患者术后血清ANXA1水平为(148.14±39.83)μg/L,明显低于术前血清ANXA1水平,差异有统计学意义(P<0.05)。结论 胆道肿瘤患者血清ANXA1水平高于健康人群,与患者体内肿瘤残留或复发密切相关,提示肿瘤患者血清的ANXA1有望成为判断胆道肿瘤残存和预测疾病进展的潜在标志物。Abstract: Objective To detect the level of annexin A1 (ANXA1) in the peripheral blood of patients with biliary tract tumors and analyze its clinical value in the early diagnosis of tumors and evaluation of disease progression. Methods The levels of serum ANXA1 before and after operation were detected by ELISA. Meanwhile, the levels of serum ANXA1 in health subjects were analyzed as controls. Results level of serum ANXA1 was (348.36 + 236.53) μg/L in patients with preoperative biliary system tumors, which were higher than that in healthy subjects (225.01 + 245.23) μg/L (P>0.05). After surgery, the level of serum ANXA1 was (148.14±39.83) μg/L, which were significantly lower than that before surgery (P<0.05). Conclusions The level of serum ANXA1 in patients with biliary tract tumors is higher than that in healthy subjects, and closely related to tumor residues or recurrence, which suggests that serum ANXA1 is a potential biomarker for judging tumor residues and predicting disease progression.
-
Keywords:
- cholangiocarcinoma /
- gallbladder /
- annexin A1
-
-
[1] Plentz RR, Malek NP. Clinical presentation, risk factors and staging systems of cholangiocarcinoma [J]. Best Pract Res Clin Gastroenterol, 2015, 29(2): 245-252. DOI: 10.1016/j.bpg.2015.02.001.
[2] Bergquist A, von Seth E. Epidemiology of cholangiocarcinoma [J]. Best Pract Res Clin Gastroenterol, 2015, 29(2): 221-232. DOI: 10.1016/j.bpg.2015.02.003.
[3] Tebar F, Gelabert-Baldrich M, Hoque M, et al. Annexins and endosomal signaling [J]. Methods Enzymol, 2014, 535: 55-74. DOI: 10.1016/B978-0-12-397925-4.00004-3.
[4] Sheikh MH, Solito E. Annexin A1: uncovering the many talents of an old protein [J/OL]. Int J Mol Sci, 2018, 19(4): pii: E1045. DOI: 10.3390/ijms19041045.
[5] Boudhraa Z, Bouchon B, Viallard C, et al. Annexin A1 localization and its relevance to cancer [J]. Clin Sci (Lond), 2016, 130(4): 205-220. DOI: 10.1042/CS20150415.
[6] Guo C, Liu S, Sun MZ. Potential role of anxa1 in cancer [J]. Future Oncol, 2013, 9(11): 1773-1793. DOI: 10.2217/fon.13.114.
[7] Liu QH, Shi ML, Bai J, et al. Identification of ANXA1 as a lymphatic metastasis and poor prognostic factor in pancreatic ductal adenocarcinoma [J]. Asian Pac J Cancer Prev, 2015, 16(7): 2719-2724.
[8] Gao Y, Chen Y, Xu D, et al. Differential expression of ANXA1 in benign human gastrointestinal tissues and cancers [J/OL]. BMC Cancer, 2014, 14: 520. DOI: 10.1186/1471-2407-14-520.
[9] Lin Y, Lin G, Fang W, et al. Increased expression of annexin A1 predicts poor prognosis in human hepatocellular carcinoma and enhances cell malignant phenotype [J/OL]. Med Oncol, 2014, 31(12): 327. DOI: 10.1007/s12032-014-0327-7.
[10] Han G, Lu K, Huang J, et al. Effect of annexin A1 gene on the proliferation and invasion of esophageal squamous cell carcinoma cells and its regulatory mechanisms [J]. Int J Mol Med, 2017, 39(2): 357-363. DOI: 10.3892/ijmm.2016.2840.
[11] Petrella A, Festa M, Ercolino SF, et al. Annexin-1 downregulation in thyroid cancer correlates to the degree of tumor differentiation [J]. Cancer Biol Ther, 2006, 5(6): 643-647. DOI: 10.4161/cbt.5.6.2700.
[12] Huang L, Liao L, Wan Y, et al. Downregulation of annexin A1 is correlated with radioresistance in nasopharyngeal carcinoma [J]. Oncol Lett, 2016, 12(6): 5229-5234. DOI : 10.3892/ol.2016.5324.
[13] Rodrigo JP, Garcia-Pedrero JM, Fernandez MP, et al. Annexin A1 expression in nasopharyngeal carcinoma correlates with squamous differentiation [J]. Am J Rhinol, 2005, 19(5): 483-487.
[14] Sato Y, Kumamoto K, Saito K, et al. Up-regulated annexin A1 expression in gastrointestinal cancer is associated with cancer invasion and lymph node metastasis [J]. Exp Ther Med, 2011, 2(2): 239-243. DOI: 10.3892/etm.2011.210.
[15] Yu G, Wang J, Chen Y, et al. Tissue microarray analysis reveals strong clinical evidence for a close association between loss of annexin A1 expression and nodal metastasis in gastric cancer [J]. Clin Exp Metastasis, 2008, 25(7): 695-702. DOI: 10.1007/s10585-008-9178-y.
[16] Okano M, Kumamoto K, Saito M, et al. Upregulated annexin A1 promotes cellular invasion in triple-negative breast cancer [J]. Oncol Rep, 2015, 33(3): 1064-1070. DOI: 10.3892/or.2015.3720.
[17] Maschler S, Gebeshuber CA, Wiedemann EM, et al. Annexin A1 attenuates EMT and metastatic potential in breast cancer [J]. EMBO Mol Med, 2010, 2(10): 401-414. DOI: 10.1002/emmm.201000095.
[18] Hongsrichan N, Rucksaken R, Chamgramol Y, et al. Annexin A1: a new immunohistological marker of cholangiocarcinoma [J]. World J Gastroenterol, 2013, 19(16): 2456-2465. DOI: 10.3748/wjg.v19.i16.2456.
[19] Wang D, Zhang H, Fang Z, et al. Annexin-1 downregulation is associated with clinical outcome in Chinese patients with hilar cholangiocarcinoma [J]. Eur Surg Res, 2010, 45(3-4): 151-157. DOI: 10.1159/000320237.
[20] Lee SH, Lee PH, Kim BG, et al. Annexin A1 in plasma from patients with bronchial asthma: its association with lung function [J/OL]. BMC Pulm Med, 2018, 18(1): 1. DOI: 10.1186/s12890-017-0557-5.
[21] Perucci LO, Carneiro FS, Ferreira CN, et al. Annexin A1 is increased in the plasma of preeclamptic women [J/OL]. PLoS One, 2015, 10(9): e0138475. DOI: 10.1371/journal.pone.0138475.
[22] 梅轶芳, 代思明, 贾浩楠, 等. 膜联蛋白A1在初治类风湿关节炎患者外周血细胞中的表达及相关因素分析[J]. 中华医学杂志, 2017, 97(25): 1937-1941. DOI: 10.3760/cma.j.issn.0376-2491.2017.25.004. [23] Huang Y, Zhang C, Chen C, et al. Investigation of circulating antibodies to ANXA1 in breast cancer [J]. Tumour Biol, 2015, 36(2): 1233-1236. DOI: 10.1007/s13277-014-2751-x.
[24] Han GH, Lu KJ, Huang JX, et al. Association of serum annexin A1 with treatment response and prognosis in patients with esophageal squamous cell carcinoma [J]. J Cancer Res Ther, 2018, 14(Supplement): S667-S674. DOI: 10.4103/0973-1482.187297.
-
期刊类型引用(3)
1. 陈晓丽，王霞，尚培中，李伟，王金，赵臣. 肝外胆管癌ANXA1和XIAP表达的临床病理研究. 河北北方学院学报(自然科学版). 2024(02): 1-5+24 . 
百度学术
2. 谢小龙，陆艳艳，虞哲科，邱振明. 胰腺癌患者血清膜联蛋白A2水平及与临床病理特征和预后的关系. 中国现代医学杂志. 2021(02): 62-66 . 百度学术
3. 夏永欣，田春阳，郭洁，张萌. 胃癌患者血清膜联蛋白A1、糖类抗原72-4、胃蛋白酶原Ⅰ及胃泌素-17水平变化及意义分析. 癌症进展. 2020(23): 2413-2416 . 百度学术
其他类型引用(0)
计量
- 文章访问数: 819
- HTML全文浏览量: 3
- PDF下载量: 91
- 被引次数: 3
下载:
.png)
