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    91例涎腺基底细胞腺瘤临床特征及组织病理学分析

    Clinical features and histopathological analysis of 91 cases of basal cell adenoma of salivary gland

    • 摘要: 目的 分析涎腺基底细胞腺瘤的临床特征及组织病理学表现,总结其临床特点和病理学特征,以提高对涎腺基底细胞腺瘤的认识和诊断水平。方法 收集徐州医科大学附属医院口腔科2009—2018年经病理确诊且临床资料完整的涎腺基底细胞腺瘤91例,分析其临床特征和组织病理学表现,并进一步分析临床特征与组织病理学之间的相关性。结果 患者发病年龄21~81岁,中位年龄(55±12.9)岁,其中女性52例,男性39例;发生于腮腺者82例,发生于颌下腺者4例,腭部3例,翼腭窝1例,牙龈1例;绝大多数患者主要临床表现为无痛性、孤立、缓慢增大的圆形或类圆形肿块,界限清楚,其中18例患者伴有局部疼痛不适症状;病理学检查结果示91例患者肿瘤直径0.8~7 cm,平均(2.4±1.1) cm。包膜完整或不明显,肿瘤主要由基底样细胞构成,可囊性变,可侵及邻近脂肪组织,可恶变。结论 涎腺基底细胞腺瘤是一种少见的良性肿瘤,好发于腮腺浅叶,临床易与其他疾病相混淆,手术切除可获得良好的疗效,临床预后良好。

       

      Abstract: Objective To analyze the clinical features and histopathological features of basal cell adenoma of the salivary gland, and to summarize its clinical features and pathological features in order to improve the understanding and diagnosis of basal cell adenoma of the salivary gland. Methods A total of 91 cases of basal cell adenomas with pathological findings and complete clinical data from 2009 to 2018 were collected. The clinical features and histopathological findings were analyzed, and the correlation between clinical features and histopathology was further analyzed. Results The age of patients was 21-81 years old, with an median age of (55±12.9) years, including 52 females and 39 males; 82 cases occurred in the parotid gland, 4 cases in the submandibular gland, 3 cases in the palate, 1 case in the pterygopalatine and 1 case in gingival site. The majority of patients presented with clinical manifestations of painless, isolated, slowly increasing round or round-like mass with clear boundaries, 18 patients with local pain symptoms. Pathological examination showed that the tumor diameter of 91 patients was 0.8-7 cm, with an average of (2.4±1.1) cm. The capsule was intact or not obvious. The tumor was mainly composed of basal like cells. It could be cystic and could invade adjacent adipose tissue, or even could be malignant. Conclusions Basal cell adenoma of salivary gland is a rare benign tumor, which is often found in the superficial lobe of parotid gland. It is easy to be confused with other diseases in clinical practice. Surgical resection can obtain good therapeutic effect and good clinical prognosis.

       

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