Abstract: Objective To study the effect and correlation of the components of different metabolic syndrome (MS) on the platelet aggregation function (PA) in patients with acute cerebral infarction (ACI). Methods A total of 152 patients with ACI hospitalized in the Affiliated Hospital of Xuzhou Medical University were selected. According to the MS diagnostic criteria, 88 patients with MS were assigned to an observation group(MS group), and 64 patients without MS were assigned to a control group(non-MS group). The clinical characteristics and platelet aggregation function of the two groups were compared. The patients with ACI were further divided into 5 groups according to the cumulative score (0-4 points) of metabolic abnormality components in MS definition. The changes of platelet aggregation function and the correlation between different MS components and platelet aggregation function were compared. Results The difference of ADP induced platelet aggregation rate (ADP%) between MS group and non-MS group was statistically significant (P<0.05). Compared with the non-MS group, triglyceride (TG), fasting blood glucose (FGB),glycated hemoglobinA1c (HbA1c), systolic blood pressure (SBP), diastolic blood pressure (DBP), waist circumference and body weight were significantly increased, while high-density lipoprotein cholesterol (HDL-C) was significantly decreased(P<0.05). One-way ANOVA showed that with the increase of MS component aggregation, ADP% gradually increased, the difference was statistically significant (P<0.05); multiple linear regression analysis showed that FGB, TG, waist circumference and ADP% were positively correlated, while HDL-C and ADP% were negatively correlated (P<0.05). Conclusions Patients with ACI and MS have higher platelet aggregation rate than those without MS. FGB, TG, waist circumference and HDL-C are important predictors of platelet aggregation in patients with ACI. With the increase of MS component aggregation, it has cumulative effect on platelet aggregation in ACI patients.