Abstract: Objective To analyze the effects of Qihuang Jiangtang capsules combined with metformin in the treatment of type 2 diabetes and insulin resistance. Methods A total of 96 patients with type 2 diabetes who were admitted into Shijiazhuang Ping'an Hospital from January 2016 to September 2017 were included. They were divided into two groups (n=48): a control group treated with metformin and an observation group treated with Qihuang Jiangtang capsules in addition to metformin. The two groups were compared for clinical efficacy. Results After treatment, both groups showed relieved traditional Chinese medicine symptoms, where lower scores were found in the observation group, compared with the control (P<0.05). Meanwhile, both groups presented remarkably reduced blood glucose indicators, where lower blood glucose indicators were detected in the observation group, compared with the control (P<0.05). Furthermore, both groups showed reduced fasting insulin (FINS) levels and improved homeostasis model assessment of insulin resistance (HOMA-IR), where lower FINS and HOMA-IR were detected in the observation group, compared with the control (P<0.05). No statistical difference was found in adverse reactions between the two groups (P/i>><0.05). Conclusions Qihuang Jiangtang capsules is helpful to relieve the clinical symptoms of type 2 diabetes patients, control blood sugar, and improve the state of insulin resistance and medication safety.