扎来普隆对利多卡因致小鼠惊厥作用的影响

陆培鑫; 高震南; 姜瑾颖; 高敏; 韩婷; 陆雯斯; 唐凌; 王倩; 王丹

doi:10.3969/j.issn.2096-3882.2020.06.015

扎来普隆对利多卡因致小鼠惊厥作用的影响

The influence of zaleplon on lidocaine-induced convulsion in mice

摘要

摘要: 目的观察不同剂量扎来普隆对利多卡因致小鼠惊厥作用的影响。方法将昆明种小鼠随机分为4组(n=10): 生理盐水(NS)组及扎来普隆2 mg·kg^-1、4 mg·kg^-1、8 mg·kg^-1(Z₂、Z₄、Z₈)组。以生理盐水或不同剂量的扎来普隆给小鼠灌胃,10 min后,各组腹腔注射利多卡因70 mg·kg^-1,观察小鼠的惊厥只数、惊厥率、惊厥潜伏期及惊厥级数。结果与NS组相比,Z₈组小鼠惊厥率明显下降(P<0.01),Z₂、Z₄、Z₈组小鼠惊厥潜伏期延长(P<0.05或P<0.01);扎来普隆使利多卡因致小鼠惊厥的级数降低(P<0.01)。结论扎来普隆能部分拮抗利多卡因的致小鼠惊厥作用。

Abstract: Objective To observe the influence of zaleplon on lidocaine-induced convulsion in mice. Methods The Kunming mice were randomly divided into four groups (n=10 each) : normal saline (NS) group, zaleplon 2 mg·kg^-1, 4 mg·kg^-1 and 8 mg·kg^-1(Z₂,Z₄,Z₈) groups. Each group received intraperitoneal lidocaine 70 mg·kg^-1 10 min after NS or different doses of zaleplon had been administered by gavage. The number of convulsive mice, incidence of convulsion, convulsion latency and convulsion level were observed. Results Compared with NS group, the incidence of convulsion declined remarkably in Z₈ group (P<0.01); the convulsion latency extended in Z₂, Z₄, Z₈ groups (P<0.05, <0.01, and<0.01). Zaleplon could reduce the convulsion level induced by lidocaine in mice (P<0.01). Conclusions Zaleplon can partially antagonize lidocaine-induced convulsion in mice.

HTML全文

参考文献(12)

施引文献

资源附件(0)