嗅觉系统炎症与帕金森病

Olfactory inflammation and Pakinson disease

摘要: 帕金森病(Parkinson disease,PD)是常见的神经系统退行性疾病,其发病机制尚未阐明。临床上,PD患者多因静止性震颤、运动迟缓等运动系统症状就诊,然而非运动系统症状如嗅觉功能障碍发生于运动症状出现前数年。近年的研究表明神经炎症是PD的重要环节,以嗅觉系统为出发点的神经炎症研究逐渐增多。本文就嗅觉系统炎症的易感性及其在PD中的研究进展进行综述。

Abstract: Pakinson disease (PD) is a common neurodegenerative disease, and its pathogenesis has not yet been clarified. Clinically, PD patients are characterized by motor symptoms such as static tremor and bradykinesia, but non-motor system symptoms, including olfactory dysfunction, occur several years before motor symptoms. Recent studies have shown that neuroinflammation plays an important role in PD, and related researches based on the olfactory system are increasing. This article reviews the susceptibility of olfactory system inflammation and its research progress in PD.