Abstract: Objective To investigate and analyze the psychological status and influencing factors of novel coronavirus pneumonia (COVID-19) patients in the intensive care unit. Methods A cross-sectional study was conducted to investigate the COVID-19 patients hospitalized in the intensive care unit of Renmin Hospital of Wuhan University from February 2, 2020 to March 5, 2020, and the Hospital Anxiety and Depression Scale and the Athens Insomnia Scale (AIS)questionnaires were used to evaluate the psychological status of the patients. Results Among the 40 confirmed COVID-19 patients in the intensive care unit, 5 cases had anxiety, 3 cases had depression and 32 cases had insomnia. The anxiety level was positively correlated with fatigue, dyspnea, myalgia and sore throat (r=0.391, 0.553, 0.458, 0.390, respectively,P＜0.05). The depression level was positively correlated with fatigue and sore throat (r=0.493 and 0.331, respectively, P＜0.05). Sleep disorders were positively correlated with fatigue and dyspnea (r= 0.403 and 0.398, respectively, P＜0.05). COVID-19 patients with different working status and educational level had significant difference in anxiety scores. There were statistically significant differences in depression scores among severe COVID-19 patients with different gender, age, working status, marital status and education level with those with severe COVID-19. Severe COVID-19 patients with different age, working status, marital status and education level had significant difference in AIS score. Conclusions The COVID-19 patients in the intensive care unit are prone to anxiety, depression and insomnia, who need more attention.