Abstract: Objective To investigate the effect of comprehensive nursing care on anxiety, depression and quality of life in patients with coronary heart disease after percutaneous coronary intervention (PCI). Methods A total of 120 inpatients with coronary heart disease were selected as subjects. They were randomly divided into an observation group and a control group (n=60). Patients in the control group were given conventional treatment and nursing care, while the observation group was given cognitive behavioral intervention and preventive care. The two groups were compared for the scores of the Self-Rating Anxiety Scale (SAS), Self-Rating Depression Scale (SDS), Ability of Daily Living Scale (ADL), Quality of Life Score (SF-36) and Seattle Angina Pectoris Questionnaire (SAQ) before and after intervention. The incidences of major adverse cardiovascular events (MACEs) in the two groups were compared before and after treatment. Results No statistical difference was found in SAS and SDS scores between the two groups before intervention (P>0.05). After intervention, the observation group produced remarkably lower SAS and SDS scores than those in the control group (P<0.05). There was no significant difference in SF-36, ADL, and SAQ scores between the two groups at admission (P>0.05). After intervention, marked increases in ADL, SF-36, and SAQ scores were found in the two groups, where the intervention group showed higher scores than the control group (P<0.05).The incidence of MACE was 5.00% for the observation group and 15.00% for the control group, which was statistically different (P<0.05). Conclusions Cognitive behavioral intervention combined with preventive nursing care can significantly improve anxiety, depression, and quality of life in patients with coronary heart disease after PCI.