Association of tumor budding with the clinicopathological characteristics and prognosis of colorectal cancer
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摘要: 目的 探讨肿瘤出芽与结直肠癌临床病理特征的关系及对结直肠癌患者预后的影响,为结直肠癌临床诊治和预后评价提供新方向。方法 选取2015年1月—12月徐州医科大学附属医院胃肠外科收治的未经放化疗的结直肠癌患者285例作为研究对象,根据肿瘤出芽水平分为低肿瘤出芽组和高肿瘤出芽组,分析肿瘤出芽与结直肠癌临床病理特征的关系;通过随访,分析肿瘤出芽与肿瘤预后的相关性。结果 高肿瘤出芽组中低组织学分级、高浸润深度和复发患者比例显著高于低肿瘤出芽组,差异有统计学意义(P<0.05);多因素COX回归分析显示,肿瘤出芽是结直肠癌患者预后的独立危险因素(HR=2.663,95%CI:1.534~3.878,P<0.001)。结论 肿瘤出芽与结直肠癌侵袭相关指标关系密切,是影响结直肠癌患者预后的重要危险因素。Abstract: Objective To explore the association of tumor budding with the clinicopathological characteristics of colorectal cancer, and its effects on the prognosis of colorectal cancer patients, so as to provide a new direction for clinical diagnosis, treatment and prognosis evaluation of colorectal cancer. Methods A total of 285 colorectal cancer patients who were admitted into Department of Gastroenterology, the Affiliated Hospital of Xuzhou Medical University from January 2015 to December 2015 and not received radiotherapy and chemotherapy were enrolled. According to the grades of tumor budding, the patients were divided into two groups: a low budding group and high a budding group. The association of tumor budding with the clinicopathological characteristics of colorectal cancer was analyzed. Meanwhile, the relationship between tumor budding and tumor prognosis was analyzed after follow-up visits. Results The proportion of patients with low histological grade, invasion type, high depth of invasion and recurrence in the high tumor budding group was significantly higher than that in the low tumor budding group (P<0.05). Multivariate Cox regression analysis showed that tumor budding was an independent risk factor for the prognosis of colorectal cancer patients (HR=2.663, 95%CI:1.534-3.878, P<0.001). Conclusions Tumor budding is associated with the invasion indicators of colorectal cancer. Tumor budding is an important risk factor for the prognosis of colorectal cancer patients.
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Keywords:
- tumor budding /
- colorectal cancer /
- pathological features /
- prognosis
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