Abstract: Objective To explore the association of neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), platelet-to-lymphocyte ratio (PLR), lactic dehydrogenase with the prognosis of patients after radical gastrectomy. Methods A total of 110 patients who underwent radical gastrectomy in Fujian Provincial Cancer Hospital were enrolled. Their pathological and follow-up data were collected. The survival rate was calculated by the Kaplan-Meier method. The differences among different groups were analyzed by Log-rank. The prognostic factors of radical gastrectomy were analyzed by Cox regression model. Results A total of 110 patients were followed-up in the current study, including 40 cases on phase Ⅰ/Ⅱ and 70 cases on phase Ⅲ. All the patients were followed up for 13-96 months, with a median follow-up time of 80.9 months. Among these 110 patients, 44 died of gastric cancer and 66 survived. According to the survival of gastric cancer patients with different clinicopathological factors, the prognosis of gastric cancer patients was statistically different from TNM stage, lymph node metastasis, NLR and LDH (P<0.05), rather than age, sex, tumor size, differentiation degree, PLR, and LMR. Patients with different NLR and PLR levels presented various degree of tumor differentiation (P<0.05). Patients with different LMR and LDH levels showed various TNM stage(P<0.05). LDH was also related to PT stage, namely local infiltration degree (P<0.05). Cox multivariate regression analysis was performed on the variables affecting the prognosis of patients with gastric cancer, and the results showed that TNM stage, NLR level and LDH were independent factors affecting the prognosis of patients with gastric cancer (P<0.05). Conclusions TNM stage, NLR level and LDH are independent factors affecting the prognosis of patients with gastric cancer.