创伤性脑损伤患者低尿酸血症发生原因及与疾病预后的关系

李可; 李洪春

doi:10.3969/j.issn.2096-3882.2021.04.014

创伤性脑损伤患者低尿酸血症发生原因及与疾病预后的关系

李可^1,2,
李洪春^1,2, ,

1. 徐州医科大学附属医院检验科, 江苏徐州 221002;
2. 徐州医科大学医学技术学院, 江苏徐州 221004

详细信息

通讯作者:
李洪春,E-mail:13775891123@163.com

中图分类号: R446.1
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出版历程
- 收稿日期: 2020-12-22
- 修回日期: 2021-04-09

Analysis of the causes of hypouricemia and its relationship with prognosis in patients with traumatic brain injury

LI Ke^1,2,
LI Hongchun^1,2, ,

1. Department of Clinical Laboratory, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221002, China;
2. School of Medical Technology, Xuzhou Medical University, Xuzhou, Jiangsu 221004

摘要

摘要: 目的研究创伤性脑损伤(traumatic brain injury,TBI)患者发生低尿酸血症原因及与预后的关系。方法选择徐州医科大学附属医院2018年6月—2019年12月符合条件的104例TBI患者,根据尿酸水平和预后情况,分为低尿酸血症组(n=52)和非低尿酸血症组(n=52),预后良好组(n=48)和预后不良组(n=56)。收集患者的影像学、实验室指标等临床资料,并记录患者Glasgow昏迷评分(GCS)和Glasgow预后评分(GOS)作为评价疾病严重程度和预后的标准。结果低尿酸血症组女性比例、GCS评分明显高于非低尿酸血症组,蛛网膜下腔出血(SAH)比例明显低于非低尿酸血症组(P<0.05)。预后良好组低尿酸血症发生率、GCS评分、白蛋白(ALB)水平等明显高于预后不良组,年龄明显低于预后不良组(P<0.05)。由年龄、低尿酸血症、入院GCS评分、ALB以及四者联合预测预后不良的ROC曲线下面积分别为0.690、0.674、0.690、0.615、0.815(P均<0.05)。结论性别、SAH、GCS评分是TBI患者发生低尿酸血症的独立影响因素,低尿酸血症是TBI预后的保护因素,可用于预测TBI患者的预后。
- 创伤性脑损伤 /
- 低尿酸血症 /
- 氧化应激 /
- 预后
Abstract: Objective To access the causes of hypouricemia and its relationship with prognosis in patients with traumatic brain injury (TBI). Methods A total of 104 TBI patients who were admitted in the Affiliated Hospital of Xuzhou Medical University from June 2018 to December 2019 were enrolled. According to their uric acid levels, they were divided into two groups (n=52): a hypouricemia group and a control group.According to their prognosis, they were divided into two groups: a good prognosis group (n=48) and a poor prognosis group (n=56). Their imaging and laboratory data were collected, and their Glasgow coma score and Glasgow prognostic score were recorded as the criteria for evaluating the severity and prognosis of the disease. Results The hypouricemia group presented remarkable increases in female percentage and GCS score as well as decreases in the percentage of subarachnoid hemorrhage (SAH),compared with the non-hypouricemia group (P<0.05). The good prognosis group showed remarkable increases in the incidence of hypouricemia, GCS score and albumin level, as well as decreases in age, compared with the poor prognosis group (P<0.05). The areas under the ROC curve to predict poor prognosis was 0.690 for age, 0.674 for hypouricemia, 0.690 for GCS score at admission, 0.615 for albumin and 0.815 for the combination of the above four factors (P<0.05). Conclusions Sex, SAH and GCS score are the independent influencing factors of hypouricemia in patients with TBI. Hypouricemia is a protective factor for the prognosis of TBI and can be used to predict the prognosis of TBI patients.
- traumatic brain injury /
- hypouricemia /
- oxidative stress /
- prognosis

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参考文献(17)

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