Abstract: Objective To describe the clinical characteristics of patients with epilepsy after ischemic stroke and investigate the diagnostic value of p38 mitogen activated protein kinase (p38MAPK) in epilepsy after ischemic stroke. Methods A total of 86 patients who were diagnosed with epilepsy after ischemic stroke in the Affiliated Xuzhou Municipal Hospital of Xuzhou Medical University from June 2015 to June 2018 were selected as a disease group, while another 86 age and sex matched patients with ischemic stroke were selected as a control group. Their general information was collected and their types of epilepsy seizure and video electroencephalogram (VEEG) results were recorded. Their levels of serum p38MAPK were detected. According to the receiver operating curve (ROC), the optimal cutoff value of p38MAPK was obtained. Results Most of patients in the disease group has partial epilepsy, with epileptiform discharge. The level of serum p38MAPK of the disease group was higher than that of the control group (P<0.05). The optimal cut-off value was 15.75 g/L, with a sensitivity of 72.1% and a specificity of 75.7%. Conclusions p38MAPK promotes the occurrence of epilepsy after ischemic stroke.