Abstract: Objective To comprehensively evaluate the effectiveness of bFGF combined with vacuum sealing drainage (VSD) in the treatment of refractory wounds. Methods Clinical studies concerning bFGF combined with VSD or traditional debridement drainage and dressing to treat refkactory wounds were retrieved in Cochrane Library, PubMed, Web of Science, EBSCO, CNKI, and Wanfang databases from establishment to April 2020. Two researchers separately conducted literature search and screening, data extraction and quality evaluation, and used RevMan 5.3.3 to analyze the extracted data. Results A total of six clinical studies with 448 patients were included in the current study. The results showed that bFGF combined with VSD was more effective than traditional debridement drainage and dressing or VSD alone RR=5.66, 95%CI (2.902, 11.03, P<0.05. Conclusions The effect of bFGF combined with VSD in the treatment of refractory wounds is better than traditional debridement drainage and dressing or VSD alone, which can effectively reduce patients' pain, save the expense, and is worth of promotion.