Abstract: Objective To investigate the effects of limited-volume fluid resuscitation on blood gas and coagulation of hemorrhagic shock patients in pre-hospital emergency treatment. Methods A total of 112 hemorrhagic shock patients who received pre-hospital emergency treatment in Medical Emergency Center of Songjiang District from August 2015 to August 2017 were enrolled. They were divided into two groups (n=56): a study group and a control group. The control group underwent routine fluid resuscitation, while the study group received limited-volume fluid resuscitation. Both groups were compared for blood gas indexes and coagulation function when entry into emergency department and 60 min, 120 min and 180 min after treatment. Results After limited-volume fluid resuscitation during pre-hospital emergency treatment, the study group presented remarkable increases in arterial partial pressure of oxygen (PaO₂) and base excess (BE) (P<0.05), as well as decreases in blood lactic acid(BC), compared with those in the control group (P<0.05). Furthermore, the study group showed remarkable decreases in prothrombin time (PT) and activated partial thromboplastin time (APTT) 60 min, 120 min and 180 min after limited-volume fluid resuscitation (P<0.05), as well as increases in PLT counts compared with the control group (P<0.05). After pre-hospital emergency treatment, the study group produced decreases in the incidence of disseminated intravascular coagulation (DIC) and mortality compared with the control group (P<0.05). Conclusions The use of limited-volume fluid resuscitation for pre-hospital emergency treatment can improve blood gas index and coagulation function, and reduce the incidence of DIC and mortality in patients with hemorrhagic shock.