Abstract: Objective To investigate the effect of nipple stimulation combined with intravenous drip of oxytocin on the labor duration and outcome of pregnant women with oligohydramnios. Methods A total of 60 pregnant women with oligohydramnios who were admitted to the Medical Campus of Qinhuai District, the General Hospital of Eastern Theater Command from June 2020 to January 2021 were enrolled. They were randomly divided into two groups (n=30): a control group and a research group. The control group was injected by intravenous drip with oxytocin, while the research group underwent effective nipple stimulation on the basis of the control group. The onset time of delivery, the first and second stage of labor duration, fetal distress, neonatal asphyxia, the bleeding rate 2 h after delivery, delivery outcome and nursing satisfaction were observed. Results Compared with the control group, the research group presented decreases in the onset time of delivery, the first and second stage of labor duration (P<0.05); decreases in the incidences of fetal distress, neonatal asphyxia and the bleeding rate 2 h after delivery (P<0.05); and increases in the rate of spontaneous delivery and nursing satisfaction (P<0.05). Conclusions For pregnant women with oligohydramnios, nipple stimulation combined with intravenous drip of oxytocin can achieve good effects, reduce the risk of delivery and guarantee the safety of mothers and newborns.