Abstract: Objective To explore the risk factors of infantile hemangioma. Methods A case-control study was conducted based on Department of Dermatology, Xuzhou Children's Hospital. The cases were composed of 248 infants with superficial infantile hemangioma, while 248 infants without infantile hemangioma with the same gender and similar of age were selected as the control group. A logistic regression model was used to analyze the risk factors of infantile hemangioma, and the odds ratio of risk factors and 95% confidence interval were calculated. Results The risk factors were birth weeks (<37 weeks: P=0.124, OR=3.523, 95%CI=0.708-17.532;37-41 weeks:P=0.559,OR=1.467,95%CI=0.405-5.315), family history (P＜0.001,OR=11.816,95%CI=3.487-40.042), placenta previa (P=0.001, OR=6.034, 95%CI=2.005-18.156), the number of births (P=0.006, OR=0.592, 95%CI=0.406-0.863), and maternal hypertension (P=0.025, OR=2.749,95%CI=1.133-6.669). Conclusions Birth weeks, family history, maternal hypertension, placenta previa and birth order are risk factors for infantile hemangioma.