Abstract: Objective To investigate the effects of high-frequency repetitive transcranial magnetic stimulation (rTMS) on the depression, anxiety and quality of life of Parkinson disease patients. Methods A total of 58 patients with Parkinson disease who were admitted to Xuzhou Renci Hospital from October 2019 to June 2022 were enrolled. According to the random number table method, they were divided into two groups in a ratio of 1∶1: a rTMS treatment group (high-frequency 5 Hz + conventional anti-PD agents) and a control group (antidepressants and anxiety agents + conventional anti-PD agents). Both groups were compared for depression, anxiety, Hoehn Yahn (H-Y) staging and quality of life scores before treatment, and postoperative 14, 30 and 90 days. Results At postoperative 14 and 30 days, both groups presented lower scores of HAMD, HAMA and PDQ-39 before those before treatment, where the rTMS treatment group was remarkably lower than the control group (P<0.05). After follow-up visit at postoperative 90 days, both groups showed lower scores of HAMD and PDQ-39 than those before treatment (P<0.05). There was no statistical difference in H-Y staging between the two groups before treatment and at postoperative 14, 30 and 90 days (P>0.05). Conclusions rTMS can significantly improve the depression, anxiety and quality of life of patients with Parkinson disease, with good safety.