Abstract: Objective To investigate the relationship between stdKt/V and related clinical indicators in patients with maintenance hemodialysis and its application value.Methods A total of 105 patients who underwent maintenance hemodialysis in Hemodialysis Center, the Affiliated Hospital of Xuzhou Medical University were selected. According to the achievement of stdKt/V, they were divided into different groups. The univariate and multiple linear regression analysis were used to screen the independent influencing factors of stdKt/V. The patients were grouped according to their stdKt/V and Kt/V values, and the differences between stdKt/V and Kt/V were compared. Patients with stdKt/V > 2.0 were investigated in groups according to dialysis frequency. Both groups were compared for general information and laboratory examination results, in order investigate the application value of stdKt/V.Results Patients in the stdKt/V >2.0 group showed higher levels of blood calcium and serum albumin, smaller dry body mass, and lower dialysis age than those in the stdKt/V ≤ 2.0 group. Multiple linear regression analysis showed that dry body mass and serum albumin levels were linearly correlated with stdKt/V, which were the independent factor of stdKt/V. Compared with patients in the all-attainment group, patients in the stdKt/V attainment and Kt/V non-attainment group had lower Kt/V values, with a higher proportion of residual renal function; there were a higher proportion of patients using dialysis twice/week regimen in the stdKt/V non-attainment and Kt/V attainment group. Compared with the three-times/week group, patients in the twice/week group had reduced Kt/V values, decreased dialysis age, increased ultrafiltration, and enhanced residual renal function and eGFR levels, without statistical differences in the remaining clinical and hematological parameters.Conclusions stdKt/V incorporates the nutritional status of dialysis patients and the volume control of the patient's body. Application of stdKt/V as a measurement of dialysis adequacy can screen out patients with different stdKt/V and Kt/V attainment, especially for those with residual renal function who dialyze twice per week, in order to compensate for the effect of Kt/V. stdKt/V can also effectively screen out patients who dialyze twice a week with dialysis adequacy, in order to assess the adequacy of dialysis.