Abstract: Objective To evaluate the therapeutic effectiveness, postoperative complications and recurrence of radiofrequency microneedling combined with negative pressure suction in the treatment of axillary osmidrosis.Methods A total of 62 patients with axillary osmidrosis were divided into three groups and underwent radiofrequency microneedling, negative pressure suction and radiofrequency microneedling combined with negative pressure suction, respectively. The three groups were compared for their therapeutic effectiveness, recurrence rate, complication rate and recovery period.Results There was no statistical difference in age, sex and the degree of axillary osmidrosis among the three groups (P>0.05). After the corresponding treatments, there was no statistical difference in the area of blue staining and the effective rate between patients with grades 1 and 2 axillary osmidrosis (P>0.05). There was no statistical difference in the area of blue staining and the effective rate in patients with grade 3 axillary osmidrosis between the radiofrequency microneedling and negative pressure suction groups (P>0.05), but the combined treatment group showed better effect than the other two groups (P<0.05). There was no statistical difference in the incidence of complications between the negative pressure suction group and the combined treatment group (P>0.05), but the radio frequency microneedling group showed better effect than the other two groups (P<0.05). There was no statistical difference in the recurrence rate between the radiofrequency microneedling and negative pressure suction groups (P>0.05), but the combined treatment group showed better effect than the other two groups (P<0.05). There was no statistical difference in the postoperative recovery period between the negative pressure suction group and the combined treatment group (P>0.05), but the radio frequency microneedling group showed better effect than the other two groups (P<0.05).Conclusions For patients with mild and moderate axillary osmidrosis, radio frequency microneedling is suggested due to a low complication rate and short recovery period. For those with severe axillary osmidrosis, combined therapy is recommended because of its good therapeutic effect and low recurrence rate.