Abstract: Currently, colorectal cancer is one of the common malignant tumors around the world, and its morbidity and mortality rates are increasing year by year in China. Early detection and treatment are of great important to improve patients' lives. However, colonoscopic pathological biopsy and colorectal cancer serum markers cannot fully achieve early diagnosis. Exosomes are double-membrane vesicle structures with a diameter of 30-140 nm, which are heterogeneous and stable and exist in almost all body fluids. Studies have shown that exosomal non-coding RNAs (miRNAs, circRNAs, and lncRNAs) are closely related to tumor development. In this paper, we summarize the recent research progress on exosomal non-coding RNAs as markers for the diagnosis and prognosis of colorectal cancer and drug resistance.