Abstract: Objective To explore the relationship between the location of glioblastoma (GBM) and its recurrence and prognosis, and to identify the risk factors influencing patient prognosis.Methods Retrospective analysis was conducted on GBM patients who were diagnosed and treated at the Affiliated Hospital of Xuzhou Medical University from January 2015 to October 2021. Their clinical, imaging, and pathological data were collected and followed up.Results A total of 94 patients were included, including 52 men and 42 women. Compared with patients whose tumors did not involve the subventricular zone (SVZ-) or cortex (CTX-), involvement of the subventricular zone (SVZ+) or cortex (CTX+) resulted in significant reduction in progression-free survival (PFS) and overall survival (OS) (both P<0.01). Patients who underwent partial resection or received adjuvant chemotherapy for less than six cycles also showed significantly reduced PFS and OS, compared with those who underwent complete resection or received adjuvant chemotherapy for six or more cycles (both P<0.01). Patients with tumors ≥5 cm in diameter, multifocal recurrence, or distant recurrence showed significantly decreased OS, compared with those with tumors <5 cm, unifocal recurrence, or local recurrence (all P<0.05). Multivariate Cox regression analysis indicated that SVZ+, CTX+, partial resection, and adjuvant chemotherapy of less than six cycles were independent risk factors affecting PFS and OS.Conclusions GBM patients with SVZ or CTX involvement are more likely to experience early recurrence, with worse prognosis. The size of primary tumor, the extent of surgical resection, the duration of adjuvant chemotherapy, and the pattern of tumor recurrence are independent factors affecting patient prognosis.