Abstract: Objective To find out the intention of perinatally depressed women and their spouses to seek professional psychological help and the influencing factors.Methods The convenient sampling method was used to select 267 pairs of perinatally depressed women and their spouses who attended the First Maternity and Infant Hospital Affiliated to Tongji University from March to June 2023 as research subjects. The study methods included a general information questionnaire, the Edinburgh Postnatal Depression Scale, a General Help-Seeking Questionnaire, and the Questionnaire of Stigma for Seeking Professional Psychological Help.Results Perinatally depressed women and their spouses scored 12.17±4.06 and 12.61±3.88 on the intention to seek professional psychological help (P＞0.05), and 21.21±5.36 and 22.58±5.61 on the Questionnaire of Stigma for Seeking Professional Psychological Help (P＜0.05). Multiple linear regression analysis indicated that history of mental illness, history of psychological help-seeking, knowledge of perinatal depression, and self-stigma were the influencing factors of perinatally depressed women's intention to seek professional psychological help (all P<0.01); and education level and public stigma were the influencing factors of spouses' intention to seek professional psychological help (P<0.05 or P<0.01).Conclusions Perinatally depressed women and their spouses' intention to seek professional psychological help is at an intermediate level, and their spouses show a higher sense of stigma than the women when seeking professional psychological help. Maternal and child health care personnel should strengthen the mental health education of couples during the perinatal period, in order to help them correctly recognize perinatal depression, understand the necessity of seeking professional psychological help, and promote couples' help-seeking behavior.