Abstract: Objective To evaluate the effects of dexmedetomidine combined with dezocine in elderly patients undergoing dilatation and curettage. MethodsA total of 40 elderly patients (70-83years older) undergoing dilatation and curettage were selected and randomly divided into two groups: group D (dexmedetomidine group) and group P (propofol group),with 20 patients in each group. The patients in group D were received dexmedetomidine(0.8 μg /kg, the infusion time was set to 10 min and the maintenance dose of dexmedetomidine injection was 0.5 μg/(kg·h), dezocine 0.1 mg/kg .The patients in group P were received propofol 1.5 mg/kg (maintenance dose of propofol was 3-6 mg/(kg·h) and dezocine 0.1 mg/kg. The mean arterial pressure (MBP), heart rate (HR) and SpO2 of the two groups were recorded before anesthesia (T0), when OAA/S ＝3 (T1), when cervical dilation started (T2) and after surgery (T3). Meanwhile, respiratory depression, glossoptosis, intraoperative awareness, sedation scores and OAA/S scores during the awaking period were also recorded. ResultsGroup D showed more stable blood pressure, a less incidence rate of respiratory depression and glossoptosis than Group P (P<0.05). Intraoperative awareness did not happen in both group, while patients in Group D showed better awareness than those in Group P (P<0.05). ConclusionIt is safe and effective to use dexmedetomidine combined with dezocine in elderly patients during diagnostic and curettage.