Abstract: Objective To observe the risk factors and coronary angiographic features of non-smoking young and middle-aged patients with acute myocardial infarction (AMI). MethodsA total of 146 non-smoking young and middle-aged patients ( ≤50 years old) who were diagnosed with AMI and underwent coronary angiography were included in the current study and their clinical data were retrospectively analyzed. Meanwhile, another 120 non-smoking young and middle-aged patients who was not diagnosed with coronary heart disease through coronary angiography CTA were selected as a control group. The relationship between body mass index (BMI), hemoglobin, total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), essential hypertension (EH), type 2 diabetes mellitus, unhealthy lifestyle and the family history of early coronary artery disease and AMI and the pathogenesis of the coronary artery were observed. ResultsCompared with the control group, the young and middle-aged patients with AMI produced higher levels of BMI, TG and LDL-C (all P<0.05). Logistic regression analysis showed that LDL-C (OR=6.083), TG (OR=3.185), EH (OR=2.129) and BMI (OR=1.119) were the independent risk factors for non-smoking young and middle-aged patients with AMI (all P<0.05). Among young and middle-aged patients with AMI, there were 132 patients with ST-segment elevation myocardial infarction, including 86 patients with single-vessel disease (43 patients with left anterior descending artery disease and 31 patients with right coronary artery disease) by coronary angiography. ConclusionsLDL-C, TG, EH and BMI are the risk factors of non-smoking young and middle-aged patients with AMI. Single vessel coronary disease is the most common coronary angiographic feature of non-smoking young and middle-aged patients with AMI.