Abstract: ObjectiveTo observe the effects of anti-epileptic drugs on the expression of major vault protein (MVP) in the peripheral blood lymphocytes of children with infantile spasm and discuss the resistant mechanism of infantile spasm. MethodsA total of 30 infantile spasm children who were admitted into our hospital from January 2014 to February 2016 were selected and set as an experimental group. Meanwhile, another 30 healthy children who underwent physical examination in our hospital was selected and set as a blank control group. After diagnosed, infantile spasm children were immediately orally administrated with sodium valproate and topiramate for more than six months. The level of MVP was detected by Western blotting before and six months after administration. ResultsA small amount of MVP was detected in the peripheral blood of the blank control group. MVP protein was highly expressed in infantile spasm children before administration, which were statistically different from those of the blank control group (P<0.05). The level of MVP was remarkably reduced in the treatment groups (P<0.05). ConclusionsMVP may play an important role in the development of resistance of infantile spasm. Sodium valproate combined with topiramate can prevent the seizure of infantile spasm children, and reduce the expression of MVP.