Abstract: ObjectiveTo evaluate the effects of etomidate combined with epidural anesthesia on the postoperative cognitive function of elderly female patients. MethodsA total of 40 elder patients scheduled for laparoscopic total hysterectomy were randomly divided into two groups: an etomidate group (Group A) and an etomidate combined with epidural anesthesia group (Group B) (n=20). Their cognitive function was assessed before operation and 1, 3 and 7 days after operation by mini-mental state examination (MMSE). The time of extubation and treatment in PACU were recorded. ResultsThere was no significant difference in MMSE score between two groups before operation and 3 and 7 days after operation (P>0.05). Meanwhile, Group A showed remarkably reduced MMSE scores than Group B 1 day after operation (P<0.05). The time for extubation and treatment in PACU in Group A were significantly longer than those in Group B (P<0.05). ConclusionsEtomidate combined with epidural anesthesia produce less effect on the postoperative cognitive function in elder patients undergoing laparoscopic total hysterectomy.