右美托咪定对乳腺癌根治术患者术后恶心呕吐的影响

李慧; 姬宁宁; 张发龙

右美托咪定对乳腺癌根治术患者术后恶心呕吐的影响

Effects of dexmedetomidine on postoperative nausea and vomiting in patients after radical mastectomy

摘要

摘要: 目的探讨右美托咪定对乳腺癌根治术患者术后恶心呕吐(PONV)的影响。方法全身麻醉下行乳腺癌根治术患者100例，随机分为右美托咪定处理组（D组）和空白对照组（C组）（n=50），麻醉诱导前分别用微量泵恒速输注右美托咪定0.3 μg/kg和生理盐水10 ml。所有患者均记录术后1、4、8、12、24、48 h的 VAS评分和Ramsay镇静评分并观察术后48 h内PONV发生率。结果D组患者术后48 h内PONV发生率明显低于C组(P<0.05)。 D组术后1、4、8、12、24、48 h VAS评分均显著低于C组（P<0.05）。2组间各时间点Ramsay评分差异无统计学意义（P＞0.05）。结论0.3 μg/kg盐酸右美托咪定能有效预防乳腺癌根治术患者PONV的发生。

Abstract: ObjectiveTo investigate the effects of dexmedetomidine on postoperative nausea and vomiting (PONV) in patients after radical mastectomy. MethodsA total of 100 patients undergoing radical mastectomy were randomly divided into two groups (n=50): a dexmedetomidine group (Group D) and a blank control group (Group C). Before anesthesia induction, 0.3 μg/kg dexmedetomidine and 10 ml normal saline were separately infused into patients. The VAS and Ramssay scores were recorded 1, 4, 8, 12, 24, and 48 h after operation and the incidence of PONV was observed. ResultsGroup D showed a remarkable reduced incidence of PCNV than Group C within 48 h after operation (P<0.05). The VAS score of Group D was lower than that of Group C 1, 4, 8, 12, 24, and 48 h after operation (P<0.05). No statistical difference was found as to Ramsay score between the two groups (P＞0.05). ConclusionsDexmedetomidine at 0.3 μg/kg can effectively prevent PONV in patients undergoing radical mastectomy.

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