Abstract: ObjectiveTo investigate the efficacy of laparoseopic radical cystectomy combined with orthotopic U-shape ileal neobladder construction to treat bladder cancer. MethodsRetrospective analysis was performed using data from eight locally advanced bladder cancer patients who underwent laparoscopie radical cystectomy and orthotopic U-shape ileal neobladder reconstruction. Transurethral resection of the bladder tumors was performed before surgery. The pathological results showed Stage T1G3 in one patient and Stage T2 in seven patients. The effects of surgical methods and intraoperative treatment on the clinical efficacy were analyzed. ResultsAll the surgeries were successfully carried out. The operation time was (348±33) min; the blood loss was (218±28) ml; the postoperative hospital stay was (24±5) days; and the recovery time of postoperative intestinal function was (3.9±0.6) days. Surgical margins were all negative. Pelvic lymph nodes were negative. Urinary fistula was reported in one patient who became cured after abdominal drainage. Intestinal fistula was reported in one patient who was cured after secondary surgery. Three patients showed good urinary control immediately after surgery, while four patients were improved after rectal training. Only one patient still had nocturnal incontinence. ConclusionsLaparoseopic radical cystectomy combined with orthotopic U-shape ileal neobladder construction is a feasible approach with small trauma, good recovery and little complications. But the surgery is difficult to be performed, and skilled surgeons are recommended.