Abstract: ObjectiveTo investigate the influence of separated disease disclosure intervention on the social support, stress and satisfaction of patients infected with human immunodeficiency virus (HIV). MethodsA total of 68 patients infected with HIV who were admitted into our hospital from November 2015 to May 2016 underwent routine follow-up nursing and set as a control group. Meanwhile, another 68 patients with HIV infection who were admitted into our hospital from June 2016 to November 2016 were provided with separated disease disclosure intervention and set as an observation group. Both groups were compared for social support, stress and satisfaction before and after nursing. ResultsAfter nursing, the observation group showed remarkably improved social support (P<0.05), less perceived and informing pressure (P<0.05), and better satisfaction (P<0.05), compared with the control. ConclusionsSeparated disease disclosure intervention to the family members of HIV carriers is helpful to improve social support towards patients with HIV infection, relieve perceived and informing pressure, and promote satisfaction.