Abstract: ObjectiveTo investigate the effects of flurbiprofen axetil on the level of plasma soluble intercellular adhesion molecule-1 (sICAM-1) and postoperative pain in patients with lower limb fracture. MethodsA total of 60 patients who were scheduled to receive surgical treatment due to acute lower limb fracture were randomly divided into two groups (n=30): a control group (Group C) and a flurbiprofen axetil group (Group F). All patients were subject to epidural anesthesia through the same route of adminiatration. Patients in Group F were intravenously injected with 1 mg/kg flurbiprofen axetil before epidural administration. The changes in their systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR) and oxygen saturation (SpO2) were recorded before anesthesia and 2 h after anesthesia. The level of plasma sICAM-1 was evaluated by ELISA before anesthesia, 2 h after anesthesia and 4 h after operation. The visual analog scale (VAS) was assessed at 1, 6, 12 and 24 h after operation. ResultsNo statistical difference was found as to age, gender, weight, the time of operation and the degree of trauma among the two groups (P>0.05). No statistical difference was found as to SBP, DBP, HR, SpO2 at each points (P>0.05). The level of plasma sICAM-1 was higher 2 h after anesthesia and 4 h after operation, compared with that before anesthesia. Compared with the Group C, the amount of plasma sICAM-1 was decreased 2 h after anesthesia and 4 h after operation. Meanwhile, the VAS was reduced at 1 h, 6 h, 12 h and 24 h after operation in Group F, compared with Group C P<0.05). ConclusionsFlurbiprofen axetil may inhibit the expression of plasma sICAM-1, and produce anti-inflammatory effects and can relieve postoperative pain in patients with lower limb fracture.