Abstract: ObjectiveTo investigate the clinical application of single-photon emission computed tomography (SPECT) based renal dynamic scintigraphy to evaluate glomerular filtration rate (GFR) in patients with renal carcinoma. MethodsRetrospective analysis was performed using the results of GFR determination from 51 patients with renal carcinoma before and one month after operation by SPECT-based renal dynamic scintigraphy. The GFRs in healthy, diseased, and both kidneys before and after surgery were compared. The effects of compensatory changes and different surgical methods on renal function were observed. ResultsFor the radical resection group, the total GFR was (55.78±7.41) ml/min after surgery, which was statistically different from the total GFR (72.75±10.85) ml/min before operation (P<0.05). For the partial resection group, the total GFR was (62.33±10.09) ml/min after operation and (67.10±12.05) ml/min before operation, without statistical difference. For those with <35 ml/min GFR in healthy kidney before operation, radical surgery was more likely to cause deterioration in renal dysfunction, compared with partial resection. ConclusionSPECT-based renal dynamic scintigraphy is useful to assess renal function and facilitate the development of surgical protocols and renal function monitoring after surgery.