Abstract: ObjectiveTo investigate the effects of progressive muscle relaxation training combined with aerobic exercise on cancer-related fatigue, negative emotion and quality of life in patients with lung cancer. MethodsA total of 56 lung caner patients who underwent routine nursing after radiotherapy from January 2015 to March 2016 in our hospital were set as a control group. Meanwhile, another 56 lung cancer patient who underwent progressive muscle relaxation training combined with aerobic exercise after radiotherapy from April 2016 to June 2017 in our hospital was set an observation group. Two groups were combined for cancer-related fatigue, negative emotions, and quality of life. ResultsThe observation group showed lower scores of behavior/severity, emotion, sensation, cognition/emotion and total score than the control (P<0.05). The SAS and SDS scores were lower in the observation group than the control (P<0.05). The body function, function, cognitive function, emotional function, social function and overall quality of life scores were significantly higher in the observation group than the control (P<0.05). ConclusionProgressive muscle relaxation training combined with aerobic exercise in lung cancer patients with radiotherapy is effective, which can effectively reduce cancer-related fatigue, relieve negative emotions, improve the quality of life and is worth promoting.