Abstract: Objective To analyze of the clinical characteristics and treatment of elderly patients with advanced non-small-cell lung cancer (NSCLC) and to explore treatment choices and prognostic factors for these patients. MethodsA total of 129 elderly patients with advanced NSCLC were enrolled. Clinical data were retrospectively analyzed in gender, smoking status, histological type, stage, Eastern Cooperative Oncology Group (ECOG) scores, treatment and prognostic factors. ResultsFor elderly patients with advanced NSCLC, their mean survival time was 20.85 months. The chemotherapy combined with targeted therapy group showed improvements in the overall objective response rate (ORR), progression-free survival (PFS) and overall survival (OS), compared with other treatment groups. According to single analysis, histological type, ECOG scores and treatment were the prognostic factors influencing OS. The multivariate analysis revealed that ECOG scores and treatment were independent prognostic factors influencing OS. ConclusionECOG scores and treatment are the independent prognostic factors for OS in elderly patients with advanced NSCLC. Elderly patients can choose the optimal treatment according to their conditions.